Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy
نویسندگان
چکیده
منابع مشابه
Dectin-1 and its role in antifungal immunity.
The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms. One such molecule is Dectin-1, a C-type lectin-like receptor which induces num...
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We recently showed that IL-13 or peroxisome proliferator activated receptor gamma (PPARgamma) ligands attenuate Candida albicans colonization of the gastrointestinal tract. Here, using a macrophage-specific Dectin-1 deficient mice model, we demonstrate that Dectin-1 is essential to control fungal gastrointestinal infection by PPARgamma ligands. We also show that the phagocytosis of yeast and th...
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متن کاملDectin-1 and Dectin-2 in innate immunity against fungi.
Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. Dectin-1 recognizes β-glucans with its CRD and transduces signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domai...
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ژورنال
عنوان ژورنال: mSphere
سال: 2019
ISSN: 2379-5042
DOI: 10.1128/msphere.00025-19